Exocytosis and Endocytosis in Neuroendocrine Cells: Inseparable Membranes!
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Exocytosis and Endocytosis in Neuroendocrine Cells: Inseparable Membranes!
Although much has been learned concerning the mechanisms of secretory vesicle formation and fusion at donor and acceptor membrane compartments, relatively little attention has been paid toward understanding how cells maintain a homeostatic membrane balance through vesicular trafficking. In neurons and neuroendocrine cells, release of neurotransmitters, neuropeptides, and hormones occurs through...
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In neuroendocrine cells, hormones and neuropeptides are released from large-dense core vesicles (secretory granules) by calcium-regulated exocytosis. Following exocytosis, compensatory uptake of membrane is required to maintain membrane homeostasis and allow recycling of secretory vesicle membranes. How these cells initiate and regulate this compensatory endocytosis remains poorly understood. O...
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thus, we will restrict our discussion to the possible physiological relevance of signaling from the endosome. Given the importance of ERKs (and PI3-K) in signaling, 20141 Milan one would predict dramatic effects of the blockade of University of Milan Medical School endocytosis on biological phenotypes. However, in the 20122 Milan few cases where biological end points were measured, The FIRC Ins...
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Exocytosis is a general term used to denote vesicle fusion at the plasma membrane, and it is the final step in the secretory pathway that typically begins in the endoplasmic reticulum (ER), passes through the Golgi apparatus, and ends at the outside of the cell. Endocytosis refers to the recovery of vesicles from the plasma membrane. Exocytotic vesicle fusion involves the coalescence of vesicle...
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2013
ISSN: 1664-2392
DOI: 10.3389/fendo.2013.00135